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CS-W001157 4
Total: USD 88.00

5-Propargylamino-dCTP

  • CAS No. 115899-39-3

  • Cat. No. CS-0149518
  • Purity≥98%
  • MDL No.MFCD28010326

*For research and further manufacturing use only, not for direct human use.

5-Propargylamino-dCTP|CS-0149518

Structure of 115899-39-3

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General Information

  • CAS No. 115899-39-3
  • Cat. No. CS-0149518
  • Purity ≥98%
  • MDL No. MFCD28010326
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₉N₄O₁₃P₃
  • Molecular Weight 520.22
  • Synonym(s) None
  • SMILES O=[P](O[P](O[P](O)(O)=O)(O)=O)(O)OC[C@@H](O1)[C@@H](O)C[C@@H]1N(C2=O)C=C(C(N)=N2)C#CCN

Description

5-Propargylamino-dCTP integrates a propargylamine handle into the cytidine scaffold, enabling site-specific bioconjugation via copper-catalyzed azide-alkyne cycloaddition. This modified nucleotide incorporates efficiently into DNA during synthesis, offering a robust strategy for labeling oligonucleotides with minimal perturbation to duplex stability.

Application

5-Propargylamino-dCTP serves as a versatile nucleoside triphosphate analog for site-specific incorporation into DNA during enzymatic synthesis. Its propargylamino group enables bioorthogonal conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC), facilitating downstream labeling, affinity capture, or probe immobilization. The compound exhibits good stability under standard polymerase reaction conditions and supports efficient enzymatic extension, making it suitable for applications in DNA tagging, sequencing, and synthetic biology workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   276.21
  • LogP   -1.8726
  • H_Acceptors   13
  • H_Donors   7
  • Rotatable_Bonds   8

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