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CS-W001157 4
Total: USD 88.00

1,1,7,7-Tetramethyl-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-8-ol

  • CAS No. 115704-83-1

  • Cat. No. CS-W021266
  • Purity≥97%
  • MDL No.MFCD00051334

*For research and further manufacturing use only, not for direct human use.

1,1,7,7-Tetramethyl-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-8-ol|CS-W021266

Structure of 115704-83-1

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General Information

  • CAS No. 115704-83-1
  • Cat. No. CS-W021266
  • Purity ≥97%
  • MDL No. MFCD00051334
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₃NO
  • Molecular Weight 245.36
  • Synonym(s) 1,1,7,7-tetramethyl-2,3,6,7-tetrahydro-1h,5h-benzo[ij]quinolizin-8-ol
  • SMILES OC1=C2C3=C(C=C1)C(C)(C)CCN3CCC2(C)C

Description

This hexahydropyridoquinolinol scaffold features a sterically shielded tertiary alcohol flanked by two methyl-substituted quinoline rings, conferring enhanced stability and reduced reactivity. The spatially constrained core facilitates selective functionalization in synthetic transformations, particularly in the construction of complex heterocyclic architectures under mild conditions.

Application

1,1,7,7-Tetramethyl-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-8-ol serves as a stable, bench-accessible heterocyclic scaffold enabling efficient construction of complex nitrogen-containing frameworks. Its tertiary alcohol functionality and fused polycyclic structure offer predictable reactivity in functional group interconversions and serve as a versatile building block in medicinal chemistry campaigns involving alkaloid-like architectures. The molecule exhibits robust handling characteristics and facilitates straightforward purification, supporting its utility in iterative synthetic sequences.

Synthesis

  • Route1
    • null|null
      1073190-52-9
    • ~50%
    • In-stock
      1,1,7,7-Tetramethyl-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-8-ol|CS-W021266
      115704-83-1

    References

    • WISTA LABORATORIES LTD.; CLUNAS, Scott; STRORY, John, Mervyn, David; RICKARD, Janet, Elizabeth; HORSLEY, David; HARRINGTON, Charles, Robert; WISCHIK, Claude, Michel Patent: WO2010/67078 A2, 2010 ; Location in patent: Page/Page column 87 ;
  • Route2
    • null|null
      1073190-53-0
    • ~78%
    • In-stock
      1,1,7,7-Tetramethyl-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-8-ol|CS-W021266
      115704-83-1

    References

    • Uddin, Md Jashim; Marnett, Lawrence J. Organic Letters, 2008 , vol. 10, # 21 p. 4799 - 4801
  • Route3
    • null|null
      115662-07-2
    • ~81%
    • In-stock
      1,1,7,7-Tetramethyl-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-8-ol|CS-W021266
      115704-83-1

    References

    • Ju, Hyun Kyung; Lim, Jong Sun; Lee, Changjin; Choi, Dong Hoon; Kim, Dong Wook Molecular Crystals and Liquid Crystals, 2008 , vol. 491, p. 152 - 163

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   3.5612
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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