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CS-W001157 4
Total: USD 88.00

5,6-Difluoropyridin-3-ol

  • CAS No. 1154579-85-7

  • Cat. No. CS-0617116
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5,6-Difluoropyridin-3-ol|CS-0617116

Structure of 1154579-85-7

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General Information

  • CAS No. 1154579-85-7
  • Cat. No. CS-0617116
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃F₂NO
  • Molecular Weight 131.08
  • Synonym(s) None
  • SMILES OC1=CC(F)=C(F)N=C1

Description

5,6-Difluoropyridin-3-ol delivers a fluorinated pyridinol scaffold with enhanced reactivity at the hydroxyl position. The ortho-fluoro substituents increase electrophilicity at the ring, enabling efficient coupling reactions under mild conditions. This bench-stable compound serves as a key building block in medicinal chemistry and agrochemical development.

Application

5,6-Difluoropyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C3 position via nucleophilic substitution due to the activating effect of the hydroxyl group and the electron-withdrawing fluorine substituents. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient synthesis of fluorinated heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.0654
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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