6-Methoxy-3,4-dihydronaphthalen-1-yl trifluoromethanesulfonate

Name: 6-Methoxy-3,4-dihydronaphthalen-1-yl trifluoromethanesulfonate
Brand: ChemScene
Availability: InStock
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CAS No. 115375-59-2
Cat. No. CS-0528766
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Methoxy-3,4-dihydronaphthalen-1-yl trifluoromethanesulfonate|CS-0528766

Structure of 115375-59-2

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Description

6-Methoxy-3,4-dihydronaphthalen-1-yl trifluoromethanesulfonate is a bench-stable, electron-rich aryl triflate featuring a polar methoxy group and a robust triflate leaving group. This combination enables efficient cross-coupling reactions under mild conditions, facilitating the rapid assembly of complex biaryl architectures in synthetic and medicinal chemistry workflows.

Application

6-Methoxy-3,4-dihydronaphthalen-1-yl trifluoromethanesulfonate serves as a robust aryl triflate handle for palladium-catalyzed cross-coupling reactions. The triflate group enables efficient Suzuki, Stille, and Negishi couplings under mild conditions, while the 6-methoxy substituent enhances solubility and stabilizes the intermediate. This scaffold offers excellent bench stability and compatibility with diverse functional groups, facilitating rapid access to substituted naphthalene derivatives in medicinal chemistry and materials synthesis.

General Information

CAS No. 115375-59-2
Cat. No. CS-0528766
Purity ≥95%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₁F₃O₄S
Molecular Weight None
Synonym(s) 6-methoxy-3,4-dihydronaphthalen-1-yl triflate
SMILES O=S(C(F)(F)F)(OC1=CCCC2=C1C=CC(OC)=C2)=O

Computational Chemistry Data

TPSA 52.6
LogP 2.8485
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 3

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Sulfonate

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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6-Methoxy-3,4-dihydronaphthalen-1-yl trifluoromethanesulfonate

CAS No. 115375-59-2

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