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5-(Aminomethyl)pyrrolidin-2-one hydrochloride

  • CAS No. 115307-13-6

  • Cat. No. CS-0075962
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-(Aminomethyl)pyrrolidin-2-one hydrochloride|CS-0075962

Structure of 115307-13-6

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General Information

  • CAS No. 115307-13-6
  • Cat. No. CS-0075962
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁ClN₂O
  • Molecular Weight 150.61
  • Synonym(s) 5-(aminomethyl)-2-pyrrolidinone hydrochloride
  • SMILES O=C1CCC(CN)N1.Cl

Description

5-(Aminomethyl)pyrrolidin-2-one hydrochloride features a pyrrolidinone core with a primary amine-bearing side chain, offering enhanced solubility and reactivity. This bench-stable derivative enables efficient incorporation into peptide conjugates and bioactive molecule scaffolds. The hydrochloride salt improves handling and storage stability under standard conditions.

Application

5-(Aminomethyl)pyrrolidin-2-one hydrochloride serves as a versatile scaffold for medicinal chemistry, enabling rapid diversification via nucleophilic substitution and reductive amination. The amine functionality facilitates conjugation with carboxylic acids, aldehydes, and electrophilic heterocycles, while the pyrrolidinone core provides metabolic stability and favorable solubility. Bench-stable and readily purified by recrystallization or ion-exchange chromatography, it functions as a key building block in the synthesis of kinase inhibitors and CNS-targeted compounds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   -0.3545
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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