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CS-W001157 4
Total: USD 88.00

(4-Methoxyphenyl)(4-nitrophenyl)methanone

  • CAS No. 1151-94-6

  • Cat. No. CS-0313310
  • Molecule weightNone
  • Purity≥96%
  • MDL No.MFCD00178348

*For research and further manufacturing use only, not for direct human use.

(4-Methoxyphenyl)(4-nitrophenyl)methanone|CS-0313310

Structure of 1151-94-6

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General Information

  • CAS No. 1151-94-6
  • Cat. No. CS-0313310
  • Purity ≥96%
  • MDL No. MFCD00178348
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₁NO₄
  • Molecular Weight None
  • Synonym(s) 4-Methoxy-4-nitrobenzophenone
  • SMILES COC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)[N+](=O)[O-]

Description

This ketone features a methoxy-substituted aryl group paired with a nitro-bearing phenyl ring, enabling precise electronic tuning for synthetic applications. The para-nitro functionality enhances electrophilicity, while the methoxy moiety provides steric and electronic modulation. Designed for stability under standard conditions, it integrates readily into cross-coupling and conjugation workflows.

Application

(4-Methoxyphenyl)(4-nitrophenyl)methanone serves as a versatile aryl ketone building block in synthetic organic chemistry, enabling efficient construction of biaryl and heterocyclic scaffolds. Its dual functionalization—electron-donating methoxy and electron-withdrawing nitro groups—facilitates directed electrophilic substitution and transition-metal-catalyzed coupling reactions. The compound exhibits good bench stability, mild handling requirements, and compatibility with standard purification techniques, making it suitable for use in medicinal chemistry campaigns and process development workflows.

Synthesis

  • Route1
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      100-66-3
    • ~88%
    • In-stock
      (4-Methoxyphenyl)(4-nitrophenyl)methanone|CS-0313310
      1151-94-6

    References

    • Organic letters, , vol. 2, # 6 p. 823 - 826
  • Route2

    References

    • Journal of Organic Chemistry, , vol. 73, # 6 p. 2420 - 2423
  • Route3
    • null|null
      122-04-3
    • ~%
    • In-stock
      (4-Methoxyphenyl)(4-nitrophenyl)methanone|CS-0313310
      1151-94-6

    References

    • Angewandte Chemie, , vol. 84, p. 294 - 295

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   69.44
  • LogP   2.8344
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   4

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