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CS-W001157 4
Total: USD 88.00

7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one

  • CAS No. 1150271-45-6

  • Cat. No. CS-0132935
  • Purity≥95%
  • MDL No.MFCD11855966

*For research and further manufacturing use only, not for direct human use.

7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one|CS-0132935

Structure of 1150271-45-6

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General Information

  • CAS No. 1150271-45-6
  • Cat. No. CS-0132935
  • Purity ≥95%
  • MDL No. MFCD11855966
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₈BNO₃
  • Molecular Weight 259.11
  • Synonym(s) Oxindole-7-boronic acid, pinacol ester
  • SMILES O=C1NC2=C(C=CC=C2B3OC(C)(C)C(C)(C)O3)C1

Description

7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one is a bench-stable boronate derivative featuring a fused indolinone core. This structure integrates a tetramethyl-substituted dioxaborolane moiety that enables efficient Suzuki-Miyaura coupling under mild conditions. The electron-deficient boronate group enhances reactivity while maintaining stability during handling and storage.

Application

7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The indolin-2-one core provides a rigid, pharmacologically relevant scaffold, while the pinacol boronate group offers excellent stability, ease of handling, and compatibility with diverse reaction conditions. It facilitates efficient C–C bond formation under mild catalytic conditions, enabling rapid diversification of indolinone-based architectures in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   47.56
  • LogP   1.4804
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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