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CS-W001157 4
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4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one

  • CAS No. 1150271-44-5

  • Cat. No. CS-0108703
  • Purity≥97%
  • MDL No.MFCD11504971

*For research and further manufacturing use only, not for direct human use.

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one|CS-0108703

Structure of 1150271-44-5

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General Information

  • CAS No. 1150271-44-5
  • Cat. No. CS-0108703
  • Purity ≥97%
  • MDL No. MFCD11504971
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₈BNO₃
  • Molecular Weight 259.11
  • Synonym(s) None
  • SMILES O=C1NC2=C(C(B3OC(C)(C)C(C)(C)O3)=CC=C2)C1

Description

This boronate-functionalized indolin-2-one integrates seamlessly into Suzuki-Miyaura cross-coupling reactions, offering a stable, bench-ready platform for constructing complex heterocyclic architectures with high functional group tolerance and predictable reactivity.

Application

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The indolin-2-one scaffold provides a rigid, electron-deficient core ideal for medicinal chemistry applications, while the tetramethylboronate group ensures excellent stability, ease of handling, and compatibility with a broad range of reaction conditions. This compound facilitates efficient C–C bond formation under mild catalytic conditions, enabling rapid access to substituted indolinone derivatives used in drug discovery and functional material synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   47.56
  • LogP   1.4804
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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