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CS-W001157 4
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(2-Isopropoxypyridin-3-yl)boronic acid

  • CAS No. 1150114-42-3

  • Cat. No. CS-0042531
  • Purity≥98%
  • MDL No.MFCD11855840

*For research and further manufacturing use only, not for direct human use.

(2-Isopropoxypyridin-3-yl)boronic acid|CS-0042531

Structure of 1150114-42-3

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General Information

  • CAS No. 1150114-42-3
  • Cat. No. CS-0042531
  • Purity ≥98%
  • MDL No. MFCD11855840
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂BNO₃
  • Molecular Weight 181.00
  • Synonym(s) 2-Isopropoxypyridine-3-boronic acid
  • SMILES CC(C)OC1=NC=CC=C1B(O)O

Description

This boronic acid features a pyridine ring functionalized with an isopropoxy group at the 2-position and a boronic acid moiety at the 3-position, enabling efficient Suzuki-Miyaura coupling. The isopropoxy substituent enhances solubility and stability under standard conditions, while the boronic acid group facilitates reliable carbon–carbon bond formation in complex molecule synthesis.

Application

(2-Isopropoxypyridin-3-yl)boronic acid serves as a versatile building block in cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds under standard Suzuki-Miyaura conditions. The isopropoxy group enhances solubility and stability, while the boronic acid functionality offers reliable reactivity with aryl halides and pseudohalides. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for medicinal chemistry campaigns and process-scale synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   62.58
  • LogP   -0.4514
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   3

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