2-Fluoro-4-nitrobenzene-1-sulfonyl chloride

Name: 2-Fluoro-4-nitrobenzene-1-sulfonyl chloride
Brand: ChemScene
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CAS No. 1146290-36-9
Cat. No. CS-0157164
Purity≥97%
MDL No.MFCD11858095

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2-Fluoro-4-nitrobenzene-1-sulfonyl chloride|CS-0157164

Structure of 1146290-36-9

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General Information

CAS No. 1146290-36-9
Cat. No. CS-0157164
Purity ≥97%
MDL No. MFCD11858095
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClFNO₄S
Molecular Weight 239.61
Synonym(s) None
SMILES C1=CC(=C(C=C1[N+](=O)[O-])F)S(=O)(=O)Cl

Description

2-Fluoro-4-nitrobenzene-1-sulfonyl chloride features a fluorine atom at the ortho position and a nitro group at the para position relative to the sulfonyl chloride, creating an electron-deficient aryl system. This combination enhances reactivity in nucleophilic aromatic substitution processes. The sulfonyl chloride moiety enables efficient coupling with amines and alcohols under mild conditions, facilitating the synthesis of sulfonamide and sulfonate derivatives. The molecule exhibits good bench stability and moisture tolerance, simplifying handling in synthetic workflows.

Application

2-Fluoro-4-nitrobenzene-1-sulfonyl chloride serves as a versatile sulfonylating agent for the synthesis of sulfonamide derivatives, enabling efficient functionalization of amines under mild conditions. Its electron-withdrawing nitro and fluorine substituents enhance reactivity while maintaining bench stability, facilitating clean reactions with broad functional group tolerance. The compound is particularly valuable in constructing heterocyclic scaffolds and bioactive intermediates common in medicinal chemistry workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

TPSA 77.28
LogP 1.6614
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Sulfonyl Chloride

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

1146290-36-9 sigma1146290-36-9 manufacturer1146290-36-9 price1146290-36-9 structure1146290-36-9 SDSbuy 1146290-36-91146290-36-9 supplier1146290-36-9 uses1146290-36-9 molecular weightprice of 1146290-36-91146290-36-9 chemical name formula of 1146290-36-9

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2-Fluoro-4-nitrobenzene-1-sulfonyl chloride

CAS No. 1146290-36-9

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