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CS-W001157 4
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7-Chloro-3,4-dihydro-2H-benzo[b][1,4]oxazine

  • CAS No. 113770-21-1

  • Cat. No. CS-W018987
  • Molecule weight169.61
  • Purity≥96%
  • MDL No.MFCD07364075

*For research and further manufacturing use only, not for direct human use.

7-Chloro-3,4-dihydro-2H-benzo[b][1,4]oxazine|CS-W018987

Structure of 113770-21-1

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General Information

  • CAS No. 113770-21-1
  • Cat. No. CS-W018987
  • Purity ≥96%
  • MDL No. MFCD07364075
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈ClNO
  • Molecular Weight 169.61
  • Synonym(s) 7-Chloro-3,4-dihydro-2H-benzo[1,4]oxazine
  • SMILES ClC1=CC2=C(C=C1)NCCO2

Description

7-Chloro-3,4-dihydro-2H-benzo[b][1,4]oxazine is a heterocyclic scaffold featuring a chlorine substituent at the 7-position, enhancing electron-withdrawing character and modulating reactivity. This bench-stable compound integrates readily into synthetic sequences requiring a rigid, oxygen-bridged ring system with tunable electronic properties.

Application

7-Chloro-3,4-dihydro-2H-benzo[b][1,4]oxazine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its chlorine substituent enhances metabolic stability and modulates electronic properties, while the dihydrooxazine core facilitates selective functionalization and coupling reactions. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, making it well-suited for modular synthesis of pharmaceutical intermediates and targeted library development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   2.1443
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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