(4-Chloro-5-fluoropyridin-2-yl)methanol

Name: (4-Chloro-5-fluoropyridin-2-yl)methanol
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CAS No. 113209-90-8
Cat. No. CS-0054816
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(4-Chloro-5-fluoropyridin-2-yl)methanol|CS-0054816

Structure of 113209-90-8

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General Information

CAS No. 113209-90-8
Cat. No. CS-0054816
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅ClFNO
Molecular Weight 161.56
Synonym(s) 4-CHLORO-5-FLUORO-2-PYRIDINEMETHANOL
SMILES OCC1=NC=C(F)C(Cl)=C1

Description

This boronate moiety integrates a 4-chloro-5-fluoropyridin-2-yl scaffold with a reactive hydroxymethyl group, enabling direct coupling in cross-coupling protocols. The electron-deficient pyridine ring enhances reactivity in palladium-catalyzed transformations, while the bench-stable alcohol functionality simplifies handling and purification.

Application

(4-Chloro-5-fluoropyridin-2-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its pyridine core supports diverse coupling reactions, while the benzylic alcohol functionality facilitates derivatization via oxidation, protection, or direct substitution. The molecule exhibits excellent bench stability and compatibility with standard purification methods, making it well-suited for multi-step synthesis and scale-up applications.

Synthesis

Route1
- 113209-89-5
- ~51%
- In-stock
  
  113209-90-8
References
- Journal of Medicinal Chemistry, , vol. 32, # 8 p. 1970 - 1977
Route2
- 108-24-7
- 113209-89-5
- ~%
- In-stock
  
  113209-90-8
References
- EP2080761 A1, ; Page/Page column 35 ;
Route3
- 80287-53-2
- ~%
- In-stock
  
  113209-90-8
References
- Journal of Medicinal Chemistry, , vol. 32, # 8 p. 1970 - 1977

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 33.12
LogP 1.3664
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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(4-Chloro-5-fluoropyridin-2-yl)methanol

CAS No. 113209-90-8

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