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CS-W001157 4
Total: USD 88.00

3-Amino-6-chloropyrazine-2-carboxamide

  • CAS No. 1125-56-0

  • Cat. No. CS-0097625
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Amino-6-chloropyrazine-2-carboxamide|CS-0097625

Structure of 1125-56-0

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General Information

  • CAS No. 1125-56-0
  • Cat. No. CS-0097625
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅ClN₄O
  • Molecular Weight 172.57
  • Synonym(s) 3-amino-6-chloro-2-Pyrazinecarboxamide
  • SMILES O=C(C1=NC(Cl)=CN=C1N)N

Description

3-Amino-6-chloropyrazine-2-carboxamide features a pyrazine core functionalized with amino, chloro, and carboxamide groups, enabling integration into diverse heterocyclic scaffolds. This electron-deficient platform supports efficient coupling reactions under standard conditions, offering robust stability for use in medicinal chemistry and materials synthesis.

Application

3-Amino-6-chloropyrazine-2-carboxamide serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrazine-based heterocycles through nucleophilic substitution and coupling reactions. Its amino and carboxamide groups offer orthogonal reactivity for late-stage functionalization, while the chloro substituent facilitates palladium-catalyzed cross-coupling. Bench-stable and readily purified by crystallization, it supports scalable synthesis of API candidates and kinase inhibitor scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   94.89
  • LogP   -0.1889
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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