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6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine

  • CAS No. 1123194-98-8

  • Cat. No. CS-0037026
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine|CS-0037026

Structure of 1123194-98-8

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General Information

  • CAS No. 1123194-98-8
  • Cat. No. CS-0037026
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀BrN₃O
  • Molecular Weight 268.11
  • Synonym(s) 6-bromo-2-methoxy-3-(4-methyl-1H-imidazole-1-yl)pyridine
  • SMILES CC1=CN(C=N1)C2=CC=C(Br)N=C2OC

Description

6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine features a brominated pyridine core paired with a methoxy group and a 4-methyl-1H-imidazolyl substituent, enabling direct coupling in palladium-catalyzed cross-coupling reactions. This bench-stable, moisture-tolerant scaffold integrates readily into complex heterocyclic architectures.

Application

6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its bromopyridine functionality. The 2-methoxy and 4-methylimidazole groups provide orthogonal reactivity and enhanced solubility, facilitating downstream modifications in API synthesis. Its bench-stable nature and compatibility with standard coupling protocols make it ideal for constructing complex heterocyclic scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.94
  • LogP   2.34682
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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