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CS-W001157 4
Total: USD 88.00

4-Bromo-2,5-difluoroaniline

  • CAS No. 112279-60-4

  • Cat. No. CS-0137491
  • Purity≥98%
  • MDL No.MFCD01861125

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2,5-difluoroaniline|CS-0137491

Structure of 112279-60-4

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General Information

  • CAS No. 112279-60-4
  • Cat. No. CS-0137491
  • Purity ≥98%
  • MDL No. MFCD01861125
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrF₂N
  • Molecular Weight 208.00
  • Synonym(s) 4-Bromo-2,5-difluoro-phenylamine
  • SMILES NC1=CC(F)=C(Br)C=C1F

Description

4-Bromo-2,5-difluoroaniline features a uniquely activated aromatic ring bearing bromo and difluoro substituents at meta and para positions relative to the amino group. This electron-deficient scaffold enables direct coupling in cross-coupling reactions and facilitates incorporation into pharmaceutical intermediates requiring halogen-directed functionalization.

Application

4-Bromo-2,5-difluoroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of substituted heterocycles via standard coupling reactions. Its orthogonal halogen functionality facilitates sequential cross-coupling protocols, while the amine group provides a handle for derivatization. The molecule exhibits good bench stability and is readily purified by standard chromatographic methods, supporting scalable synthesis workflows.

Synthesis

  • Route1

    References

    • EP224001 B1, ;
  • Route2
    • null|null
      75-09-2
    • In-stock
      2,5-Difluoroaniline|CS-W019973
      367-30-6
    • null|null
      7732-18-5
    • ~97%
    • In-stock
      4-Bromo-2,5-difluoroaniline|CS-0137491
      112279-60-4

    References

    • US4863959 A1, ;
  • Route3

    References

    • US5888421 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.3095
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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