1-Cbz-3-Aminoazetidine

Name: 1-Cbz-3-Aminoazetidine
Brand: ChemScene
Availability: InStock
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CAS No. 112257-20-2
Cat. No. CS-W007058
Purity≥95%
MDL No.MFCD07772068

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

Structure of 112257-20-2

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Description

1-Cbz-3-Aminoazetidine features a protected primary amine within a strained four-membered ring, enabling direct incorporation into peptide-like scaffolds. The Cbz group ensures stability during synthesis and facilitates selective deprotection. This scaffold delivers enhanced conformational rigidity for medicinal chemistry applications.

Application

1-Cbz-3-Aminoazetidine serves as a versatile building block for the synthesis of azetidine-containing heterocycles, offering a protected amine functionality that enables straightforward derivatization. The Cbz group provides excellent bench stability and facilitates purification via standard chromatographic methods. It participates reliably in nucleophilic substitution, reductive amination, and coupling reactions, making it well-suited for medicinal chemistry campaigns targeting kinase inhibitors and other bioactive scaffolds.

General Information

CAS No. 112257-20-2
Cat. No. CS-W007058
Purity ≥95%
MDL No. MFCD07772068
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₄N₂O₂
Molecular Weight 206.24
Synonym(s) Benzyl 3-aminoazetidine-1-carboxylate
SMILES NC1CN(C(OCC2=CC=CC=C2)=O)C1

Computational Chemistry Data

TPSA 55.56
LogP 0.9661
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-Cbz-3-Aminoazetidine

CAS No. 112257-20-2

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