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CS-W001157 4
Total: USD 88.00

2-Amino-4-bromobenzamide

  • CAS No. 112253-70-0

  • Cat. No. CS-0044167
  • Purity≥98%
  • MDL No.MFCD12674809

*For research and further manufacturing use only, not for direct human use.

2-Amino-4-bromobenzamide|CS-0044167

Structure of 112253-70-0

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General Information

  • CAS No. 112253-70-0
  • Cat. No. CS-0044167
  • Purity ≥98%
  • MDL No. MFCD12674809
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BrN₂O
  • Molecular Weight 215.05
  • Synonym(s) 2-amino-4-bromo-benzamide
  • SMILES O=C(N)C1=CC=C(Br)C=C1N

Description

2-Amino-4-bromobenzamide features a brominated aromatic ring paired with complementary amine and amide functional groups, enabling direct incorporation into diverse synthetic scaffolds. This bench-stable compound serves as a key intermediate in the development of bioactive molecules and pharmaceutical candidates.

Application

2-Amino-4-bromobenzamide serves as a versatile building block in medicinal chemistry, enabling direct incorporation into heterocyclic scaffolds via amidation, Suzuki-Miyaura coupling, or electrophilic substitution. The amino and bromo groups offer orthogonal reactivity for sequential functionalization, while the amide functionality ensures stability and solubility in polar solvents. Its bench-stable crystalline form facilitates handling and purification in multi-step synthesis workflows.

Synthesis

  • Route1

    References

    • TIBOTEC PHARMACEUTICALS; VANDYCK, Koen; VERSCHUEREN, Wim Gaston; RABOISSON, Pierre Jean-Marie Bernard Patent: WO2012/13643 A1, 2012 ; Location in patent: Page/Page column 48 ;
  • Route2
    • 4-Bromo-2-nitrobenzamide|CS-0734566
      1152237-09-6
    • ~66%
    • In-stock
      2-Amino-4-bromobenzamide|CS-0044167
      112253-70-0

    References

    • Lipford, Grayson B.; Zepp, Charles M.; Nguyen, Toan B. Patent: US2010/160314 A1, 2010 ; Location in patent: Page/Page column 69 ;
  • Route3
    • 4-Bromo-2-nitrobenzonitrile|CS-W006045
      79603-03-5
    • ~%
    • In-stock
      2-Amino-4-bromobenzamide|CS-0044167
      112253-70-0

    References

    • Kitano, Yasunori; Kawahara, Eiji; Suzuki, Tsuyoshi; Abe, Daisuke; Nakajou, Masahiro; Ueda, Naoko Patent: US2004/116422 A1, 2004 ; Location in patent: Page/Page column 31-32 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   69.11
  • LogP   1.1302
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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