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CS-W001157 4
Total: USD 88.00

6-Methyl-2-pyridinecarboxaldehyde

  • CAS No. 1122-72-1

  • Cat. No. CS-W007849
  • Purity≥95%
  • MDL No.MFCD00006291

*For research and further manufacturing use only, not for direct human use.

6-Methyl-2-pyridinecarboxaldehyde|CS-W007849

Structure of 1122-72-1

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General Information

  • CAS No. 1122-72-1
  • Cat. No. CS-W007849
  • Purity ≥95%
  • MDL No. MFCD00006291
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO
  • Molecular Weight 121.14
  • Synonym(s) 6-Methylpyridine-2-carboxaldehyde
  • SMILES O=CC1=NC(C)=CC=C1

Description

MMAE is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. Monomethyl auristatin E or MMAE is 100-1000 times more potent than doxorubicin. It is a very potent antimitotic agent that inhibits cell division by blocking the polymerization of tubulin.

Synthesis

  • Route1

    References

    • US2005/124807 A1, ; Page/Page column 11 ;
  • Route2

    References

    • Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2719 - 2724
  • Route3

    References

    • Tetrahedron Letters, , vol. 40, # 9 p. 1635 - 1636

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.20252
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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