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CS-W001157 4
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Ethyl glutamate

  • CAS No. 1119-33-1

  • Cat. No. CS-0085963
  • Purity≥97%
  • MDL No.MFCD00037217

*For research and further manufacturing use only, not for direct human use.

Ethyl glutamate|CS-0085963

Structure of 1119-33-1

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General Information

  • CAS No. 1119-33-1
  • Cat. No. CS-0085963
  • Purity ≥97%
  • MDL No. MFCD00037217
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₃NO₄
  • Molecular Weight 175.18
  • Synonym(s) None
  • SMILES N[C@@H](CCC(OCC)=O)C(O)=O

Description

Ethyl glutamate features a readily hydrolyzable ester group paired with a protected α-amino functionality, enabling controlled delivery in peptide synthesis. This bifunctional architecture integrates seamlessly into chain elongation protocols, offering enhanced solubility and stability under standard reaction conditions.

Application

Ethyl glutamate serves as a versatile building block in peptide synthesis and medicinal chemistry, offering reliable amine protection and hydrolytic stability under standard conditions. Its ethyl ester functionality facilitates efficient coupling reactions, while the α-amino and γ-carboxylate groups enable orthogonal reactivity in multistep syntheses. The compound exhibits excellent bench stability and simplifies purification in solid-phase and solution-phase workflows.

Synthesis

  • Route1
    • null|null
      64-17-5
    • In-stock
      L-Glutamic acid|CS-0003473
      56-86-0
    • ~72%
    • In-stock
      Ethyl glutamate|CS-0085963
      1119-33-1

    References

    • Albert, Rainer; Danklmaier, Johann; Hoenig, Helmut; Kandolf, Harald Synthesis, 1987 , # 7 p. 635 - 637
  • Route2
    • null|null
      64-17-5
    • Benzyl n-[(3S)-2,6-dioxooxan-3-yl]carbamate|CS-0256477
      4124-76-9
    • ~%
    • In-stock
      Ethyl glutamate|CS-0085963
      1119-33-1
    • In-stock
      Pemetrexed impurity 25|CS-0164018
      52454-78-1

    References

    • Yakugaku Zasshi, , vol. 73, p. 397 Chem.Abstr., , p. 2597
  • Route3
    • Glutamic acid diethyl ester|CS-0108420
      16450-41-2
    • ~78%
    • In-stock
      Ethyl glutamate|CS-0085963
      1119-33-1

    References

    • Ager, David J.; Babler, Scott; Erickson, Robert A.; Froen, Diane E.; Kittleson, Jeannine; Pantaleone, David P.; Prakash, Indra; Zhi, Ben Organic Process Research and Development, 2004 , vol. 8, # 1 p. 72 - 85

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   89.62
  • LogP   -0.2584
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   5

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