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CS-W001157 4
Total: USD 88.00

O-Phospho-L-threonine

  • CAS No. 1114-81-4

  • Cat. No. CS-0059358
  • Purity≥97%
  • MDL No.MFCD00080958

*For research and further manufacturing use only, not for direct human use.

O-Phospho-L-threonine|CS-0059358

Structure of 1114-81-4

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General Information

  • CAS No. 1114-81-4
  • Cat. No. CS-0059358
  • Purity ≥97%
  • MDL No. MFCD00080958
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₀NO₆P
  • Molecular Weight 199.10
  • Synonym(s) None
  • SMILES N[C@@H]([C@H](OP(O)(O)=O)C)C(O)=O

Description

O-Phospho-L-threonine delivers a phosphorylated threonine scaffold ideal for probing kinase activity and signaling pathways. This stable, water-soluble analog features a phosphate group at the hydroxyl position, enabling direct incorporation into peptide substrates or enzymatic assays under physiological conditions.

Application

O-Phospho-L-threonine serves as a key phosphorylated amino acid building block for the synthesis of phosphopeptides and protein kinase substrates. Its stable phosphate ester group enables reliable incorporation into peptide sequences, facilitating studies of post-translational modification. The compound exhibits good bench stability and compatibility with standard solid-phase peptide synthesis protocols, supporting efficient coupling and orthogonal deprotection strategies.

Synthesis

  • Route1

    References

    • Biochemical Journal, , vol. 35, p. 461,462

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅰ
Hazard Statements : H314-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501

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Computational Chemistry Data

  • TPSA   130.08
  • LogP   -1.1039
  • H_Acceptors   4
  • H_Donors   4
  • Rotatable_Bonds   4

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