5-Methoxy-1H-pyrazol-3-amine hydrochloride

Name: 5-Methoxy-1H-pyrazol-3-amine hydrochloride
Brand: ChemScene
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CAS No. 110884-53-2
Cat. No. CS-0050450
Molecule weightNone
Purity≥97%
MDL No.MFCD17392863

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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5-Methoxy-1H-pyrazol-3-amine hydrochloride|CS-0050450

Structure of 110884-53-2

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General Information

CAS No. 110884-53-2
Cat. No. CS-0050450
Purity ≥97%
MDL No. MFCD17392863
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₈ClN₃O
Molecular Weight None
Synonym(s) 3-amino-5-methoxypyrazole hydrochloride
SMILES Cl.COC1=CC(N)=NN1

Description

5-Methoxy-1H-pyrazol-3-amine hydrochloride features a pyrazole core with a methoxy group at the 5-position and a primary amine at the 3-position, delivering enhanced solubility and stability under standard conditions. This bench-stable derivative serves as a key intermediate in medicinal chemistry, enabling efficient coupling reactions and facilitating access to diverse heterocyclic scaffolds for drug discovery applications.

Application

5-Methoxy-1H-pyrazol-3-amine hydrochloride serves as a versatile building block for heterocyclic synthesis, enabling efficient access to substituted pyrazole scaffolds. Its amine functionality facilitates direct coupling reactions and derivatization under mild conditions, while the methoxy group provides orthogonal reactivity and enhanced solubility. The hydrochloride salt ensures excellent bench stability and ease of handling, making it well-suited for medicinal chemistry campaigns and API intermediate development.

Synthesis

Route1
- 70138-31-7
- ~%
- In-stock
  
  110884-53-2
References
- WO2008/117050 A1, ; Page/Page column 69 ; WO 2008/117050 A1
Route2
- 41307-23-7
- ~98%
- In-stock
  
  110884-53-2
References
- Journal of Medicinal Chemistry, , vol. 54, # 1 p. 262 - 276

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 63.93
LogP 0.4223
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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5-Methoxy-1H-pyrazol-3-amine hydrochloride

CAS No. 110884-53-2

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