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CS-W001157 4
Total: USD 88.00

DMT-2'-OMe-Bz-C

  • CAS No. 110764-74-4

  • Cat. No. CS-0172865
  • Purity≥96%
  • MDL No.MFCD00226243

*For research and further manufacturing use only, not for direct human use.

DMT-2'-OMe-Bz-C|CS-0172865

Structure of 110764-74-4

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General Information

  • CAS No. 110764-74-4
  • Cat. No. CS-0172865
  • Purity ≥96%
  • MDL No. MFCD00226243
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₈H₃₇N₃O₈
  • Molecular Weight 663.72
  • Synonym(s) None
  • SMILES O[C@H]1[C@@H](OC)[C@H](N2C(N=C(NC(C3=CC=CC=C3)=O)C=C2)=O)O[C@@H]1COC(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6

Description

DMT-2'-OMe-Bz-C delivers a protected nucleoside building block featuring a benzoyl group at the 2'-position and a methoxy substitution, enabling selective coupling in oligonucleotide synthesis. This derivative combines enhanced stability with efficient incorporation under standard conditions, supporting streamlined phosphoramidite workflows.

Application

DMT-2'-OMe-Bz-C serves as a key building block for the synthesis of modified oligonucleotides, enabling site-specific incorporation of 2'-O-methyl and benzoyl-protected ribose units. Its robust DMT group ensures efficient purification via reverse-phase chromatography, while the 2'-OMe-Bz moiety provides enhanced nuclease resistance and improved binding affinity. The compound exhibits excellent stability under standard phosphoramidite coupling conditions and facilitates reliable synthesis of complex antisense constructs.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   130.37
  • LogP   4.7948
  • H_Acceptors   10
  • H_Donors   2
  • Rotatable_Bonds   12

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