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CS-W001157 4
Total: USD 88.00

(S,S)-QuinoxP

  • CAS No. 1107608-80-9

  • Cat. No. CS-0086064
  • Purity≥95%
  • MDL No.MFCD10567042

*For research and further manufacturing use only, not for direct human use.

(S,S)-QuinoxP|CS-0086064

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General Information

  • CAS No. 1107608-80-9
  • Cat. No. CS-0086064
  • Purity ≥95%
  • MDL No. MFCD10567042
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₂₈N₂P₂
  • Molecular Weight None
  • Synonym(s) (S) QuinoxP
  • SMILES C[P@@](C(C)(C)C)C1=NC2=CC=CC=C2N=C1[P@](C(C)(C)C)C

Description

(S,S)-QuinoxP is a chiral bis-oxazoline ligand featuring two quinoxaline-derived heterocycles, designed for asymmetric transition-metal catalysis. This rigid, electron-rich scaffold enables high enantioselectivity in copper- and zinc-mediated reactions, particularly in C–C bond formation. The (S,S) configuration ensures optimal stereocontrol in catalytic cycles, offering robust performance under standard bench conditions with minimal decomposition.

Application

(S,S)-QuinoxP serves as a robust chiral ligand in asymmetric catalysis, enabling high enantioselectivity in palladium- and nickel-catalyzed cross-coupling reactions. Its rigid quinoxaline backbone and sterically defined (S,S)-configured phosphine groups provide excellent functional group tolerance and bench stability, facilitating efficient synthesis of enantiopure biaryl and heteroaryl scaffolds commonly found in pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335-H413
Precautionary Statements : P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   4.7008
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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