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CS-W001157 4
Total: USD 88.00

1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene

  • CAS No. 1103738-29-9

  • Cat. No. CS-M2123
  • Purity≥97%
  • MDL No.MFCD18642361

*For research and further manufacturing use only, not for direct human use.

1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene|CS-M2123

Structure of 1103738-29-9

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General Information

  • CAS No. 1103738-29-9
  • Cat. No. CS-M2123
  • Purity ≥97%
  • MDL No. MFCD18642361
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₄ClIO
  • Molecular Weight 372.63
  • Synonym(s) Benzene, 1-chloro-2-[(4-ethoxyphenyl)methyl]-4-iodo-
  • SMILES CCOC1=CC=C(CC2=CC(I)=CC=C2Cl)C=C1

Description

1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene features a strategically positioned iodine atom enabling efficient cross-coupling reactions, while the ethoxybenzyl group enhances solubility and stability under standard conditions. This aryl halide integrates seamlessly into Suzuki-Miyaura and Stille coupling workflows, delivering high functional group tolerance and predictable reactivity in complex synthesis.

Application

1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene serves as a versatile bifunctional building block for Suzuki-Miyaura and Stille coupling reactions. The chloro group enables palladium-catalyzed cross-coupling under standard conditions, while the iodobenzene moiety offers high reactivity in similar transformations. Its ethoxybenzyl side chain provides steric and electronic modulation, enhancing solubility and stability during synthetic sequences. This compound facilitates efficient construction of complex biaryl architectures common in pharmaceutical and agrochemical research.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   4.9341
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   4

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