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CS-W001157 4
Total: USD 88.00

ALDH1A inhibitor 673A

  • CAS No. 109437-62-9

  • Cat. No. CS-0090400
  • Purity≥98%
  • MDL No.MFCD02904606

*For research and further manufacturing use only, not for direct human use.

ALDH1A inhibitor 673A|CS-0090400

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General Information

  • CAS No. 109437-62-9
  • Cat. No. CS-0090400
  • Purity ≥98%
  • MDL No. MFCD02904606
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₃NO
  • Molecular Weight 223.27
  • Synonym(s) ALDH1Ai 673A
  • SMILES O=CC1=CC=C(N2CC3=C(C=CC=C3)C2)C=C1

Description

673A is a potent, selective inhibitor of the ALDH1A enzyme family, designed for precise modulation of aldehyde dehydrogenase activity in cellular systems. This compound features a unique heterocyclic scaffold that enables high-affinity binding and effective intracellular penetration. It serves as a critical tool for studying cancer stem cell metabolism and redox regulation pathways.

Application

673A serves as a potent and selective inhibitor of ALDH1A isoforms, enabling targeted modulation of aldehyde metabolism in cellular systems. Its stable pyridine core and electron-withdrawing substituents confer enhanced metabolic stability and favorable pharmacokinetic properties. The compound functions effectively in vitro to suppress retinoic acid biosynthesis and demonstrates utility in studies probing cancer stem cell pathways and oxidative stress responses.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   3.0193
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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