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CS-W001157 4
Total: USD 88.00

6-Ethynyl-1H-indazole

  • CAS No. 1093847-80-3

  • Cat. No. CS-0050210
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Ethynyl-1H-indazole|CS-0050210

Structure of 1093847-80-3

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General Information

  • CAS No. 1093847-80-3
  • Cat. No. CS-0050210
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆N₂
  • Molecular Weight 142.16
  • Synonym(s) None
  • SMILES C#CC1=CC2=C(C=NN2)C=C1

Description

6-Ethynyl-1H-indazole is a bench-stable, moisture-tolerant heterocyclic building block featuring a terminal alkyne group at the 6-position of the indazole core. This functionality enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for conjugation in bioorthogonal labeling and click chemistry applications. The electron-deficient indazole scaffold supports diverse downstream transformations in medicinal chemistry and materials science.

Application

6-Ethynyl-1H-indazole serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized heterocycles via copper-catalyzed coupling reactions. Its terminal alkyne moiety facilitates reliable Sonogashira and click-type conjugations, while the indazole core provides inherent stability and compatibility with diverse reaction conditions. The compound exhibits excellent bench stability, ease of purification, and broad functional group tolerance, making it well-suited for medicinal chemistry lead optimization and the construction of complex API scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.5442
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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