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1-Methyl-1H-indazole-6-carbaldehyde

  • CAS No. 1092351-51-3

  • Cat. No. CS-0037487
  • Purity≥98%
  • MDL No.MFCD11109366

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1H-indazole-6-carbaldehyde|CS-0037487

Structure of 1092351-51-3

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General Information

  • CAS No. 1092351-51-3
  • Cat. No. CS-0037487
  • Purity ≥98%
  • MDL No. MFCD11109366
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O
  • Molecular Weight 160.17
  • Synonym(s) 6-Formyl-1-methyl-1H-indazole
  • SMILES CN1C2=C(C=CC(=C2)C=O)C=N1

Description

1-Methyl-1H-indazole-6-carbaldehyde features a conjugated aldehyde group positioned at the 6-position of a methyl-substituted indazole core. This electron-deficient carbonyl integrates readily into multicomponent reactions, serving as a key building block for heterocyclic scaffolds in medicinal chemistry and materials science.

Application

1-Methyl-1H-indazole-6-carbaldehyde serves as a versatile building block for medicinal chemistry and heterocyclic synthesis, enabling efficient functionalization at the C6 position. Its aldehyde group facilitates reductive amination, Grignard additions, and condensation reactions with hydrazines or amines, while the indazole core provides metabolic stability and favorable pharmacophore properties. Bench-stable and readily purified by flash chromatography, it functions effectively in standard coupling protocols and scaffold diversification campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   34.89
  • LogP   1.3858
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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