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CS-W001157 4
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H-Glu(OtBu)-NH2 hydrochloride

  • CAS No. 108607-02-9

  • Cat. No. CS-0130757
  • Purity≥95%
  • MDL No.MFCD00237067

*For research and further manufacturing use only, not for direct human use.

H-Glu(OtBu)-NH2 hydrochloride|CS-0130757

Structure of 108607-02-9

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General Information

  • CAS No. 108607-02-9
  • Cat. No. CS-0130757
  • Purity ≥95%
  • MDL No. MFCD00237067
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₉ClN₂O₃
  • Molecular Weight 238.71
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)CC[C@H](N)C(N)=O.[H]Cl

Description

H-Glu(OtBu)-NH2 (hydrochloride) features a protected glutamic acid side chain and an amine-terminus, enabling direct incorporation into peptide sequences. This bench-stable derivative simplifies synthesis workflows by eliminating the need for on-resin deprotection steps. The hydrochloride salt enhances solubility in aqueous and polar organic solvents, streamlining handling during automated and manual peptide assembly.

Application

H-Glu(OtBu)-NH₂ (hydrochloride) serves as a robust building block for peptide synthesis, offering a protected glutamic acid side chain with enhanced solubility and stability. The OtBu group provides orthogonal protection for the carboxylic acid functionality, enabling selective deprotection during sequence assembly. This derivative facilitates efficient coupling reactions and simplifies purification in solid-phase and solution-phase workflows, making it well-suited for the construction of complex peptide scaffolds and bioactive sequences.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   95.41
  • LogP   0.3427
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   4

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