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CS-W001157 4
Total: USD 88.00

4-Cyclopropyl-1,2,5-oxadiazole-3-carboxylic acid

  • CAS No. 1083246-26-7

  • Cat. No. CS-0498540
  • Purity≥95%
  • MDL No.MFCD26937744

*For research and further manufacturing use only, not for direct human use.

4-Cyclopropyl-1,2,5-oxadiazole-3-carboxylic acid|CS-0498540

Structure of 1083246-26-7

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General Information

  • CAS No. 1083246-26-7
  • Cat. No. CS-0498540
  • Purity ≥95%
  • MDL No. MFCD26937744
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₃
  • Molecular Weight 154.12
  • Synonym(s) None
  • SMILES O=C(C1=NON=C1C2CC2)O

Description

4-Cyclopropyl-1,2,5-oxadiazole-3-carboxylic acid features a stable oxadiazole core with a cyclopropyl substituent enhancing lipophilicity and metabolic resilience. This scaffold delivers a rigid, electron-deficient platform ideal for bioisosteric replacement in medicinal chemistry. The carboxylic acid group enables direct conjugation or salt formation, facilitating integration into peptide macrocycles and drug candidates requiring precise polarity modulation.

Application

4-Cyclopropyl-1,2,5-oxadiazole-3-carboxylic acid serves as a stable, bench-accessible building block for heterocyclic synthesis. Its oxadiazole core exhibits enhanced metabolic stability and favorable polarity, enabling efficient incorporation into bioactive scaffolds. The carboxylic acid functionality facilitates direct coupling reactions or derivatization, supporting applications in medicinal chemistry and API development. Functions effectively in standard amide bond formation and transition-metal-catalyzed transformations with good functional group tolerance.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   76.22
  • LogP   0.6452
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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