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CS-W001157 4
Total: USD 88.00

5-(Trifluoromethyl)pyridine-2,3-diamine

  • CAS No. 107867-51-6

  • Cat. No. CS-0097703
  • Purity≥96%
  • MDL No.MFCD10696252

*For research and further manufacturing use only, not for direct human use.

5-(Trifluoromethyl)pyridine-2,3-diamine|CS-0097703

Structure of 107867-51-6

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General Information

  • CAS No. 107867-51-6
  • Cat. No. CS-0097703
  • Purity ≥96%
  • MDL No. MFCD10696252
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆F₃N₃
  • Molecular Weight None
  • Synonym(s) 5-(trifluoromethyl)-2,3-pyridinediamine
  • SMILES NC1=NC=C(C(F)(F)F)C=C1N

Description

5-(Trifluoromethyl)pyridine-2,3-diamine features a pyridine core functionalized with a trifluoromethyl group and two adjacent amino substituents, delivering enhanced electron density and improved solubility in polar solvents. This arrangement supports efficient coupling reactions and facilitates incorporation into bioactive scaffolds. The diamine moiety enables versatile coordination in metal complexes, while the trifluoromethyl group imparts metabolic stability and modulates lipophilicity. This compound serves as a key building block for pharmaceutical intermediates and advanced ligands.

Application

5-(Trifluoromethyl)pyridine-2,3-diamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling and cyclization reactions. Its dual amine functionality and electron-withdrawing trifluoromethyl group provide enhanced solubility, metabolic stability, and favorable electronic properties for target-directed drug discovery. The compound exhibits good bench stability and compatibility with common protecting group strategies, facilitating efficient purification and integration into complex molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.93
  • LogP   1.2648
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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