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(S)-tert-Butyl (pyrrolidin-3-ylmethyl)carbamate hydrochloride

  • CAS No. 1075260-66-0

  • Cat. No. CS-0047921
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-tert-Butyl (pyrrolidin-3-ylmethyl)carbamate hydrochloride|CS-0047921

Structure of 1075260-66-0

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General Information

  • CAS No. 1075260-66-0
  • Cat. No. CS-0047921
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₁ClN₂O₂
  • Molecular Weight 236.74
  • Synonym(s) tert-butyl N-{[(3S)-pyrrolidin-3-yl]methyl}carbamate hydrochloride
  • SMILES Cl.CC(C)(C)OC(=O)NC[C@H]1CCNC1

Description

This bench-stable, moisture-tolerant chiral building block features a pyrrolidin-3-ylmethyl moiety tethered to a tert-butyl carbamate group, enabling direct incorporation into asymmetric synthesis. The hydrochloride salt enhances solubility and handling in aqueous or polar organic media, streamlining access to biologically relevant heterocycles and peptide analogs.

Application

(S)-tert-Butyl (pyrrolidin-3-ylmethyl)carbamate hydrochloride serves as a chiral building block for the synthesis of pyrrolidine-containing scaffolds in medicinal chemistry. The protected amine enables selective functionalization and orthogonal deprotection, while the tert-butyl carbamate group offers excellent bench stability and ease of purification. It functions as a key intermediate in the construction of bioactive heterocycles and peptide analogs requiring stereocontrolled pyrrolidine incorporation.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P233-P260-P261-P264-P280-P302+P352-P304+P340-P340-P362-P403-P405-P501

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Computational Chemistry Data

  • TPSA   50.36
  • LogP   1.5424
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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