2-(Difluoromethyl)quinoline

Name: 2-(Difluoromethyl)quinoline
Brand: ChemScene
Availability: InStock
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CAS No. 1075184-01-8
Cat. No. CS-0155991
Molecule weight179.17
Purity≥97%
MDL No.MFCD11226558

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 1075184-01-8
Cat. No. CS-0155991
Purity ≥97%
MDL No. MFCD11226558
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₇F₂N
Molecular Weight 179.17
Synonym(s) None
SMILES C1=CC=C2C(=C1)C=CC(=N2)C(F)F

Description

2-(Difluoromethyl)quinoline features a strategically positioned difluoromethyl group that enhances metabolic stability and modulates electronic properties within the quinoline scaffold. This substitution imparts improved lipophilicity and electron-withdrawing character, making it a valuable building block for medicinal chemistry applications. The molecule exhibits bench-stable handling characteristics and compatibility with standard synthetic protocols.

Application

2-(Difluoromethyl)quinoline serves as a valuable building block in medicinal chemistry, offering a unique combination of electronic and steric properties. The difluoromethyl group enhances metabolic stability and modulates lipophilicity, while the quinoline core provides a versatile scaffold for further functionalization. It reacts predictably in standard coupling and electrophilic substitution reactions, enabling efficient access to complex heterocyclic systems. Its bench-stable nature and compatibility with common synthetic protocols make it ideal for iterative synthesis workflows in drug discovery.

Synthesis

Route1
- 1382716-43-9
- ~70%
- In-stock
  
  1075184-01-8
References
- Huang, Weizhou; Ni, Chuanfa; Zhao, Yanchuan; Zhang, Wei; Dilman, Alexander D.; Hu, Jinbo Tetrahedron, 2012 , vol. 68, # 26 p. 5137 - 5144
Route2
- In-stock
  
  6560-83-4
- ~%
- In-stock
  
  1075184-01-8
References
- Fujikawa, Kenichi; Fujioka, Yasutaka; Kobayashi, Akira; Amii, Hideki Organic Letters, 2011 , vol. 13, # 20 p. 5560 - 5563

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 12.89
LogP 3.1724
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Key Words

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2-(Difluoromethyl)quinoline

CAS No. 1075184-01-8

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