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CS-W001157 4
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Imidazole-5-propionic acid

  • CAS No. 1074-59-5

  • Cat. No. CS-0038274
  • Purity≥97%
  • MDL No.MFCD00237415

*For research and further manufacturing use only, not for direct human use.

Imidazole-5-propionic acid|CS-0038274

Structure of 1074-59-5

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General Information

  • CAS No. 1074-59-5
  • Cat. No. CS-0038274
  • Purity ≥97%
  • MDL No. MFCD00237415
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O₂
  • Molecular Weight 140.14
  • Synonym(s) Imidazolepropionic acid
  • SMILES C(CC(=O)O)C1=CN=CN1

Description

Imidazole-5-propionic acid delivers a polar, heterocyclic scaffold with enhanced solubility and metabolic stability. This functionalized imidazole integrates readily into bioactive molecules, serving as a key pharmacophore in kinase inhibitors and peptide mimetics. Its side chain enables conjugation without compromising ring integrity under standard conditions.

Synthesis

  • Route1

    References

    • Journal of Medicinal Chemistry, , vol. 54, # 6 p. 1693 - 1703
  • Route2
    • methyl 3-(1H-imidazol-5-yl)propanoate|CS-0037183
      31434-93-2
    • ~%
    • In-stock
      Imidazole-5-propionic acid|CS-0038274
      1074-59-5

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 13 p. 3972 - 3976
  • Route3
    • null|null
      4708-67-2
    • ~%
    • In-stock
      Imidazole-5-propionic acid|CS-0038274
      1074-59-5

    References

    • Chemische Berichte, , vol. 66, p. 151,158 Nippon Kagaku Kaishi, , vol. 52, p. 844,850

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   0.4269
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   3

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