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CS-W001157 4
Total: USD 88.00

5-Methyl-2-nitropyridine

  • CAS No. 1074-38-0

  • Cat. No. CS-W002554
  • Purity≥97%
  • MDL No.MFCD00234182

*For research and further manufacturing use only, not for direct human use.

5-Methyl-2-nitropyridine|CS-W002554

Structure of 1074-38-0

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General Information

  • CAS No. 1074-38-0
  • Cat. No. CS-W002554
  • Purity ≥97%
  • MDL No. MFCD00234182
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₂
  • Molecular Weight 138.12
  • Synonym(s) 6-Nitro-3-picoline
  • SMILES O=[N+](C1=NC=C(C)C=C1)[O-]

Description

5-Methyl-2-nitropyridine features a nitro group at the 2-position and a methyl substituent at the 5-position of the pyridine ring, creating a strongly electron-deficient heteroaromatic system. This configuration enhances reactivity in nucleophilic substitution and metal-catalyzed coupling processes. The compound exhibits bench-stable handling characteristics and serves as a key building block in pharmaceutical intermediates and agrochemical synthesis.

Application

5-Methyl-2-nitropyridine serves as a versatile building block in synthetic organic chemistry, enabling the construction of functionalized heterocycles via selective nitro group reduction and subsequent coupling reactions. Its methyl and nitro substituents provide orthogonal reactivity for downstream modifications, including nucleophilic substitution and transition-metal-catalyzed cross-couplings. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Krohn, Karsten; Kuepke, Jochen; Rieger, Hagen Advanced Synthesis and Catalysis, 1997 , vol. 339, # 4 p. 335 - 339
  • Route2
    • In-stock
      2-Amino-5-methylpyridine|CS-D0808
      1603-41-4
    • null|null
      7722-84-1
    • ~%
    • In-stock
      5-Methyl-2-nitropyridine|CS-W002554
      1074-38-0

    References

    • Journal of the American Chemical Society, , vol. 73, p. 494

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.29822
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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