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CS-W001157 4
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2-(2,3-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 1073339-17-9

  • Cat. No. CS-0120178
  • Purity≥97%
  • MDL No.MFCD12405347

*For research and further manufacturing use only, not for direct human use.

2-(2,3-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0120178

Structure of 1073339-17-9

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General Information

  • CAS No. 1073339-17-9
  • Cat. No. CS-0120178
  • Purity ≥97%
  • MDL No. MFCD12405347
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅BF₂O₂
  • Molecular Weight 240.05
  • Synonym(s) 2,3-Difluorophenylboronic acid pinacol ester
  • SMILES FC1=C(C=CC=C1B2OC(C)(C(C)(O2)C)C)F

Description

This boronate ester features a 2,3-difluorophenyl moiety coupled to a tetramethyl-1,3,2-dioxaborolane ring, delivering enhanced stability and reactivity in Suzuki-Miyaura cross-coupling. The electron-withdrawing fluorine substituents modulate reactivity while maintaining bench-stable handling under standard conditions.

Application

2-(2,3-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. Its tetramethyl-substituted dioxaborolane ring enhances air and moisture stability, enabling reliable coupling with aryl, heteroaryl, and vinyl halides under standard conditions. The 2,3-difluorophenyl moiety provides orthogonal reactivity and is commonly found in bioactive scaffolds, making this reagent ideal for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.264
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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