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CS-W001157 4
Total: USD 88.00

3-Amino-4,6-dichloropicolinic acid

  • CAS No. 1073182-87-2

  • Cat. No. CS-0100911
  • Molecule weight207.01
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Amino-4,6-dichloropicolinic acid|CS-0100911

Structure of 1073182-87-2

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General Information

  • CAS No. 1073182-87-2
  • Cat. No. CS-0100911
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄Cl₂N₂O₂
  • Molecular Weight 207.01
  • Synonym(s) 3-amino-4,6-dichloro-pyridine-2-carboxylic acid
  • SMILES O=C(O)C1=NC(Cl)=CC(Cl)=C1N

Description

3-Amino-4,6-dichloropicolinic acid features a strategically positioned amino group flanked by two chlorine atoms on the picolinic acid scaffold. This electron-deficient heterocycle integrates readily into medicinal chemistry scaffolds, offering enhanced solubility and metabolic stability in bioactive molecule design.

Application

3-Amino-4,6-dichloropicolinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its orthogonal functional groups—amino and carboxylic acid—facilitate diverse transformations including amidation, coupling reactions, and cyclization. The electron-withdrawing dichloro substituents enhance reactivity in electrophilic substitution and improve metabolic stability in downstream candidates. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   76.21
  • LogP   1.6688
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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