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CS-W001157 4
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(6-Chloro-2-methoxypyridin-3-yl)boronic acid

  • CAS No. 1072946-50-9

  • Cat. No. CS-0063872
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(6-Chloro-2-methoxypyridin-3-yl)boronic acid|CS-0063872

Structure of 1072946-50-9

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General Information

  • CAS No. 1072946-50-9
  • Cat. No. CS-0063872
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BClNO₃
  • Molecular Weight 187.39
  • Synonym(s) 6-Chloro-2-methoxypyridine-3-boronic acid
  • SMILES COC1=NC(Cl)=CC=C1B(O)O

Description

This boronate moiety features a chlorine-substituted pyridine core with a methoxy group at the 2-position, delivering enhanced stability and selective reactivity in cross-coupling processes. The electron-deficient heteroaromatic scaffold enables efficient palladium-catalyzed transformations under standard conditions.

Application

(6-Chloro-2-methoxypyridin-3-yl)boronic acid serves as a versatile building block in palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. The chloropyridine moiety supports orthogonal functionalization, while the boronic acid group offers excellent bench stability and compatibility with Suzuki-Miyaura coupling conditions. Its methoxy substituent enhances solubility and modulates electronic properties, facilitating downstream derivatization in medicinal chemistry and materials synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   62.58
  • LogP   -0.5766
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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