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CS-W001157 4
Total: USD 88.00

5-(4-Morpholinyl)-2-pyridinecarboxylic acid

  • CAS No. 1072103-29-7

  • Cat. No. CS-0060454
  • Molecule weight208.22
  • Purity≥98%
  • MDL No.MFCD18251373

*For research and further manufacturing use only, not for direct human use.

5-(4-Morpholinyl)-2-pyridinecarboxylic acid|CS-0060454

Structure of 1072103-29-7

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General Information

  • CAS No. 1072103-29-7
  • Cat. No. CS-0060454
  • Purity ≥98%
  • MDL No. MFCD18251373
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂N₂O₃
  • Molecular Weight 208.22
  • Synonym(s) 5-morpholin-4-ylpyridine-2-carboxylic acid
  • SMILES C1=CC(=NC=C1N2CCOCC2)C(=O)O

Description

5-Morpholinopicolinic acid is a polar, bench-stable heterocyclic carboxylic acid featuring a morpholine ring fused to a picolinic backbone. This structural motif delivers enhanced solubility and metabolic stability, making it a valuable scaffold in medicinal chemistry for drug discovery applications.

Application

5-Morpholinopicolinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its pyridine core with ortho-morpholino substitution provides favorable solubility, metabolic stability, and functional group tolerance, facilitating downstream derivatization via amidation, esterification, or transition-metal-catalyzed coupling reactions. The compound exhibits bench stability and is amenable to purification by recrystallization or chromatography, supporting its use in scalable synthetic routes for drug discovery campaigns.

Synthesis

  • Route1
    • null|null
      1301214-68-5
    • ~71%
    • In-stock
      5-(4-Morpholinyl)-2-pyridinecarboxylic acid|CS-0060454
      1072103-29-7

    References

    • PFIZER INC.; BAGLEY, Scott William; GRIFFITH, David Andrew; KUNG, Daniel Wei-Shung Patent: WO2011/58473 A1, 2011 ; Location in patent: Page/Page column 30 ;
  • Route2
    • Diethyl 2-(5-nitropyridin-2-yl)malonate|CS-0326875
      60891-70-5
    • ~%
    • In-stock
      5-(4-Morpholinyl)-2-pyridinecarboxylic acid|CS-0060454
      1072103-29-7

    References

    • PFIZER INC.; BAGLEY, Scott William; GRIFFITH, David Andrew; KUNG, Daniel Wei-Shung Patent: WO2011/58473 A1, 2011 ;
  • Route3

    References

    • PFIZER INC.; BAGLEY, Scott William; GRIFFITH, David Andrew; KUNG, Daniel Wei-Shung Patent: WO2011/58473 A1, 2011 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   62.66
  • LogP   0.6164
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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