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CS-W001157 4
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1-Methyl-1H-indazole-4-carboxylic acid

  • CAS No. 1071433-05-0

  • Cat. No. CS-0052468
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1H-indazole-4-carboxylic acid|CS-0052468

Structure of 1071433-05-0

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General Information

  • CAS No. 1071433-05-0
  • Cat. No. CS-0052468
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O₂
  • Molecular Weight 176.17
  • Synonym(s) 1-Methylindazole-4-carboxylic acid
  • SMILES CN1N=CC2=C(C=CC=C12)C(O)=O

Description

1-Methyl-1H-indazole-4-carboxylic acid features a rigid, electron-deficient indazole core paired with a methylated nitrogen and a carboxylic acid group at the 4-position. This combination enables direct integration into bioactive scaffolds, particularly in kinase inhibitors and pharmaceutical intermediates, where its polarity and hydrogen-bonding capacity enhance target engagement. The compound exhibits bench-stable handling characteristics under standard conditions.

Application

1-Methyl-1H-indazole-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to indazole-based scaffolds through standard amide coupling and decarboxylation protocols. Its carboxylic acid functionality exhibits excellent compatibility with common coupling reagents, while the methylated indazole core provides enhanced metabolic stability and favorable solubility profiles for downstream applications in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   1.2715
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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