Lot numbers can be found on the outside label of a product:
1-Bromo-4-(2,2,2-trifluoroethoxy)benzene
-
CAS No. 106854-77-7
- Cat. No. CS-W021309
- Purity≥96%
- MDL No.MFCD07780193
*For research and further manufacturing use only, not for direct human use.
Structure of 106854-77-7
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 106854-77-7
- Cat. No. CS-W021309
- Purity ≥96%
- MDL No. MFCD07780193
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₆BrF₃O
- Molecular Weight 255.03
- Synonym(s) UKRORGSYN-BB BBV-081072
- SMILES FC(F)(F)COC1=CC=C(Br)C=C1
Description
1-Bromo-4-(2,2,2-trifluoroethoxy)benzene features a bromine substituent and a trifluoroethoxy group positioned para to one another on the benzene ring. This electronic configuration enhances its utility in palladium-catalyzed cross-coupling reactions, where the electron-deficient aryl halide integrates efficiently with diverse nucleophiles. The trifluoroethoxy moiety imparts improved metabolic stability and lipophilicity, beneficial for medicinal chemistry applications.
Application
1-Bromo-4-(2,2,2-trifluoroethoxy)benzene serves as a versatile aryl halide building block in cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. The trifluoroethoxy group enhances metabolic stability and modulates electronic properties, while the bromine center provides high reactivity in Pd-catalyzed couplings. Bench-stable and compatible with standard purification protocols, it facilitates streamlined synthesis of fluorinated aromatic scaffolds relevant to agrochemical and pharmaceutical development.
Synthesis
-
Route1
-
106-41-2 -
In-stock
433-06-7 - ~54%
-
In-stock
106854-77-7
References
-
VIAMET PHARMACEUTICALS, INC.; HOEKSTRA, William J.; SCHOTZINGER, Robert J.; RAFFERTY, Stephen W. Patent: WO2013/109998 A1, 2013 ; Location in patent: Page/Page column 41 ;
-
-
Route2
-
106-41-2
-
6226-25-1
- ~99%
-
In-stock
106854-77-7
References
-
ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2005/822 A1, 2005 ; Location in patent: Page/Page column 44 ; WO 2005/000822 A1
-
-
Route3
-
In-stock
25236-64-0 -
95-56-7
- ~30%
-
In-stock
106854-77-7
References
-
Dublanchet, Anne-Claude; Compere, Delphine; Cluzeau, Philippe; Blais, Stephane; Denis, Alexis; Ducrot, Pierre; Courte, Karine; Descamps, Sophie Patent: US2004/72871 A1, 2004 ; Location in patent: Page/Page column 23 ;
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 9.23
- LogP 3.3902
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 2
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene sigma1-Bromo-4-(2,2,2-trifluoroethoxy)benzene manufacturer1-Bromo-4-(2,2,2-trifluoroethoxy)benzene price1-Bromo-4-(2,2,2-trifluoroethoxy)benzene structure1-Bromo-4-(2,2,2-trifluoroethoxy)benzene SDSbuy 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene1-Bromo-4-(2,2,2-trifluoroethoxy)benzene supplier1-Bromo-4-(2,2,2-trifluoroethoxy)benzene uses1-Bromo-4-(2,2,2-trifluoroethoxy)benzene molecular weightprice of 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene1-Bromo-4-(2,2,2-trifluoroethoxy)benzene chemical name formula of 1-Bromo-4-(2,2,2-trifluoroethoxy)benzene