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CS-W001157 4
Total: USD 88.00

Methyl 2,4-difluorobenzoate

  • CAS No. 106614-28-2

  • Cat. No. CS-W004937
  • Purity≥98%
  • MDL No.MFCD03093799

*For research and further manufacturing use only, not for direct human use.

Methyl 2,4-difluorobenzoate|CS-W004937

Structure of 106614-28-2

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General Information

  • CAS No. 106614-28-2
  • Cat. No. CS-W004937
  • Purity ≥98%
  • MDL No. MFCD03093799
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆F₂O₂
  • Molecular Weight 172.13
  • Synonym(s) 2,4-DIFLUORO-BENZOIC ACID METHYL ESTER
  • SMILES O=C(OC)C1=CC=C(F)C=C1F

Application

Methyl 2,4-difluorobenzoate serves as a versatile building block in medicinal chemistry and synthetic organic chemistry. Its ortho- and meta-fluorine substituents enable selective electrophilic substitution and facilitate transition-metal-catalyzed coupling reactions. The ester group provides a handle for controlled hydrolysis or reduction, while the molecule exhibits excellent bench stability and compatibility with diverse reaction conditions.

Synthesis

  • Route1

    References

    • US6194461 B1, ;
  • Route2
    • null|null
      67-56-1
    • In-stock
      2,4-Difluorobenzoyl chloride|CS-W017394
      72482-64-5
    • ~99%
    • In-stock
      Methyl 2,4-difluorobenzoate|CS-W004937
      106614-28-2

    References

    • WO2007/68619 A1, ; Page/Page column 97 ; WO 2007/068619 A1
  • Route3
    • null|null
      124-38-9
    • In-stock
      2,4-Difluoro-1-iodobenzene|CS-W010293
      2265-93-2
    • null|null
      74-88-4
    • ~65%
    • In-stock
      Methyl 2,4-difluorobenzoate|CS-W004937
      106614-28-2

    References

    • Journal of Organic Chemistry, , vol. 70, # 11 p. 4314 - 4317

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H302-H315-H318-H335
Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.7514
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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