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CS-W001157 4
Total: USD 88.00

(Aminomethyl)phosphonic acid

  • CAS No. 1066-51-9

  • Cat. No. CS-0085750
  • Molecule weight111.04
  • Purity≥97%
  • MDL No.MFCD00008105

*For research and further manufacturing use only, not for direct human use.

(Aminomethyl)phosphonic acid|CS-0085750

Structure of 1066-51-9

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General Information

  • CAS No. 1066-51-9
  • Cat. No. CS-0085750
  • Purity ≥97%
  • MDL No. MFCD00008105
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula NH₂CH₂P(O)(OH)₂
  • Molecular Weight 111.04
  • Synonym(s) None
  • SMILES OP(O)(CN)=O

Description

(Aminomethyl)phosphonic acid features a phosphonic acid group directly linked to an aminomethyl moiety, delivering strong metal-chelating capability and enhanced solubility in aqueous systems. This combination enables robust coordination with transition metals and facilitates use in catalytic processes and bioconjugation strategies under standard laboratory conditions.

Application

(Aminomethyl)phosphonic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of phosphonate-containing bioactive molecules. Its stable phosphonic acid group and primary amine functionality offer orthogonal reactivity for peptide coupling, metal coordination, and heterocycle construction. The compound exhibits excellent bench stability and compatibility with standard purification techniques, facilitating its use in multi-step syntheses of kinase inhibitors and enzyme substrates.

Synthesis

  • Route1
    • Hydroxymethylphosphonic acid|CS-0757558
      2617-47-2
    • ~0%
    • In-stock
      (Aminomethyl)phosphonic acid|CS-0085750
      1066-51-9

    References

    • Monsanto Technology LLC Patent: US2005/54871 A1, 2005 ; Location in patent: Page/Page column 34 ;
  • Route2
    • null|null
      115989-10-1
    • ~0%
    • In-stock
      (Aminomethyl)phosphonic acid|CS-0085750
      1066-51-9

    References

    • Monsanto Technology LLC Patent: US2005/54871 A1, 2005 ; Location in patent: Page/Page column 34 ;
  • Route3

    References

    • US2328358 , ; Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 224, p. 406,407 Annales de Chimie (Cachan, France), , vol. <12>4, p. 377

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   83.55
  • LogP   -0.9197
  • H_Acceptors   2
  • H_Donors   3
  • Rotatable_Bonds   1

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