Fmoc-N-Me-HomoPhe-OH

Name: Fmoc-N-Me-HomoPhe-OH
Brand: ChemScene
Availability: InStock
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CAS No. 1065076-30-3
Cat. No. CS-0372410
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 1065076-30-3

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General Information

CAS No. 1065076-30-3
Cat. No. CS-0372410
Purity ≥97%
MDL No. None
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₆H₂₅NO₄
Molecular Weight 415.48
Synonym(s) None
SMILES OC([C@H](CCC1=CC=CC=C1)N(C)C(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O

Description

Fmoc-N-Me-HomoPhe-OH is a sterically hindered, bench-stable amino acid derivative featuring a methoxy-substituted phenylalanine backbone. This N-methylated variant enhances membrane permeability and resistance to enzymatic degradation, making it ideal for solid-phase peptide synthesis of bioactive sequences requiring improved stability and lipophilicity.

Application

Fmoc-N-Me-HomoPhe-OH serves as a valuable building block in peptide synthesis, enabling the incorporation of N-methylated homophenylalanine residues with enhanced metabolic stability. The Fmoc group provides orthogonal protection for the α-amino function, while the N-methyl substitution reduces hydrogen-bonding capacity and improves membrane permeability. This derivative exhibits excellent bench stability, facilitates efficient coupling under standard conditions, and supports straightforward purification via flash chromatography.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 66.84
LogP 4.9533
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 7

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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Fmoc-N-Me-HomoPhe-OH

CAS No. 1065076-30-3

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