3,6-Dichloro-1,2,4,5-tetrazine

Name: 3,6-Dichloro-1,2,4,5-tetrazine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 106131-61-7
Cat. No. CS-0049617
Purity≥95%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3,6-Dichloro-1,2,4,5-tetrazine|CS-0049617

Structure of 106131-61-7

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 106131-61-7
Cat. No. CS-0049617
Purity ≥95%
MDL No. None
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂Cl₂N₄
Molecular Weight 150.95
Synonym(s) Dichloro-s-tetrazine
SMILES ClC1=NN=C(Cl)N=N1

Description

3,6-Dichloro-1,2,4,5-tetrazine features a highly reactive tetrazine core with two chlorine substituents at the 3 and 6 positions, enabling efficient inverse electron-demand Diels-Alder reactions. This bench-stable compound integrates readily into bioorthogonal labeling workflows, offering rapid conjugation kinetics with strained dienophiles. The electron-deficient framework enhances selectivity in complex biological environments.

Application

3,6-Dichloro-1,2,4,5-tetrazine serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of nitrogen-rich heterocycles and functionalized scaffolds. Its reactive dichloro substituents facilitate selective nucleophilic substitution under mild conditions, offering high functional group tolerance and compatibility with common coupling protocols. The compound exhibits excellent bench stability and simplifies purification in multi-step syntheses, making it well-suited for the development of advanced intermediates in medicinal chemistry and materials science applications.

Synthesis

Route1
- 5940-53-4
- ~82%
- In-stock
  
  106131-61-7
References
- Gong, Yong-Hua; Miomandre, Fabien; Meallet-Renault, Rachel; Badre, Sophie; Galmiche, Laurent; Tang, Jie; Audebert, Pierre; Clavier, Gilles European Journal of Organic Chemistry, 2009 , # 35 p. 6121 - 6128
Route2
- In-stock
  
  1672-34-0
- ~67%
- In-stock
  
  106131-61-7
References
- Dalla Via, Lisa; Gonzalez-Gomez, Jose Carlos; Perez-Montoto, Lazaro Guillermo; Santana, Lourdes; Uriarte, Eugenio; Marciani Magno, Sebastiano; Gia, Ornella Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 10 p. 2874 - 2876

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 51.56
LogP 0.5734
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Other aromatic heterocycles compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry Catalysts, Ligands, Reagents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry Tetrazines

Key Words

3,6-Dichloro-1,2,4,5-tetrazine sigma3,6-Dichloro-1,2,4,5-tetrazine manufacturer3,6-Dichloro-1,2,4,5-tetrazine price3,6-Dichloro-1,2,4,5-tetrazine structure3,6-Dichloro-1,2,4,5-tetrazine SDSbuy 3,6-Dichloro-1,2,4,5-tetrazine3,6-Dichloro-1,2,4,5-tetrazine supplier3,6-Dichloro-1,2,4,5-tetrazine uses3,6-Dichloro-1,2,4,5-tetrazine molecular weightprice of 3,6-Dichloro-1,2,4,5-tetrazine3,6-Dichloro-1,2,4,5-tetrazine chemical name formula of 3,6-Dichloro-1,2,4,5-tetrazine

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

3,6-Dichloro-1,2,4,5-tetrazine

CAS No. 106131-61-7

Recommended Products