Ethyl 2-(4-bromopyridin-2-yl)acetate

Name: Ethyl 2-(4-bromopyridin-2-yl)acetate
Brand: ChemScene
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CAS No. 1060814-91-6
Cat. No. CS-W020454
Purity≥96%
MDL No.MFCD10566271

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Ethyl 2-(4-bromopyridin-2-yl)acetate|CS-W020454

Structure of 1060814-91-6

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General Information

CAS No. 1060814-91-6
Cat. No. CS-W020454
Purity ≥96%
MDL No. MFCD10566271
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₀BrNO₂
Molecular Weight 244.09
Synonym(s) None
SMILES CCOC(=O)Cc1cc(Br)ccn1

Description

Ethyl 2-(4-bromopyridin-2-yl)acetate features a brominated pyridine core paired with an acetyl ester side chain, enabling direct coupling in cross-coupling reactions. This bench-stable building block integrates readily into synthetic sequences requiring halogen-directed functionalization or transition metal catalysis.

Application

Ethyl 2-(4-bromopyridin-2-yl)acetate serves as a versatile building block in cross-coupling chemistry, enabling efficient palladium-catalyzed transformations to access functionalized pyridine derivatives. The bromopyridine moiety facilitates Suzuki, Stille, and Negishi couplings, while the ester group offers orthogonal reactivity for further derivatization. Bench-stable and readily purified by column chromatography, it functions reliably in medicinal chemistry campaigns and process development workflows.

Synthesis

Route1
- In-stock
  
  22282-99-1
- 105-58-8
- ~84%
- In-stock
  
  1060814-91-6
References
- VITAE PHARMACEUTICALS, INC.; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LEFTHERIS, Katerina; ZHUANG, Linghang; TICE, Colin, M.; SINGH, Suresh, B.; YE, Yuanjie; XU, Zhenrong; HIMMELSBACH, Frank; ECKHARDT, Matthias Patent: WO2011/159760 A1, 2011 ; Location in patent: Page/Page column 73 ; WO 2011/159760 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 39.19
LogP 1.9497
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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Ethyl 2-(4-bromopyridin-2-yl)acetate

CAS No. 1060814-91-6

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