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CS-W001157 4
Total: USD 88.00

6-Bromo-4-chloronicotinaldehyde

  • CAS No. 1060811-24-6

  • Cat. No. CS-0097277
  • Purity≥97%
  • MDL No.MFCD13188856

*For research and further manufacturing use only, not for direct human use.

6-Bromo-4-chloronicotinaldehyde|CS-0097277

Structure of 1060811-24-6

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General Information

  • CAS No. 1060811-24-6
  • Cat. No. CS-0097277
  • Purity ≥97%
  • MDL No. MFCD13188856
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClNO
  • Molecular Weight 220.45
  • Synonym(s) 6-Bromo-4-chloro-pyridine-3-carbaldehyde
  • SMILES O=CC1=C(Cl)C=C(Br)N=C1

Description

6-Bromo-4-chloronicotinaldehyde is a halogenated pyridine aldehyde featuring complementary reactive handles for cross-coupling and functionalization. The para-halogenated scaffold enables efficient Pd-catalyzed transformations, while the aldehyde group serves as a direct anchor for reductive amination or imine formation under mild conditions. This bench-stable reagent integrates seamlessly into synthetic sequences requiring selective installation of electron-deficient heterocyclic motifs.

Application

6-Bromo-4-chloronicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling and condensation reactions. Its dual halogenation pattern supports sequential functionalization, while the aldehyde group facilitates imine formation and cyclization processes. Bench-stable and readily purified by flash chromatography, it functions efficiently in multi-step syntheses requiring orthogonal reactivity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.31
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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