6-Bromo-4-chloronicotinaldehyde

Name: 6-Bromo-4-chloronicotinaldehyde
Brand: ChemScene
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CAS No. 1060811-24-6
Cat. No. CS-0097277
Purity≥97%
MDL No.MFCD13188856

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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6-Bromo-4-chloronicotinaldehyde|CS-0097277

Structure of 1060811-24-6

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Description

6-Bromo-4-chloronicotinaldehyde is a halogenated pyridine aldehyde featuring complementary reactive handles for cross-coupling and functionalization. The para-halogenated scaffold enables efficient Pd-catalyzed transformations, while the aldehyde group serves as a direct anchor for reductive amination or imine formation under mild conditions. This bench-stable reagent integrates seamlessly into synthetic sequences requiring selective installation of electron-deficient heterocyclic motifs.

Application

6-Bromo-4-chloronicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling and condensation reactions. Its dual halogenation pattern supports sequential functionalization, while the aldehyde group facilitates imine formation and cyclization processes. Bench-stable and readily purified by flash chromatography, it functions efficiently in multi-step syntheses requiring orthogonal reactivity.

General Information

CAS No. 1060811-24-6
Cat. No. CS-0097277
Purity ≥97%
MDL No. MFCD13188856
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃BrClNO
Molecular Weight 220.45
Synonym(s) 6-Bromo-4-chloro-pyridine-3-carbaldehyde
SMILES O=CC1=C(Cl)C=C(Br)N=C1

Computational Chemistry Data

TPSA 29.96
LogP 2.31
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Aldehyde

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Bromo-4-chloronicotinaldehyde

CAS No. 1060811-24-6

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