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CS-W001157 4
Total: USD 88.00

3-Fluoro-4-methoxypyridine

  • CAS No. 1060805-03-9

  • Cat. No. CS-0040329
  • Molecule weight127.12
  • Purity≥97%
  • MDL No.MFCD13185605

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-4-methoxypyridine|CS-0040329

Structure of 1060805-03-9

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General Information

  • CAS No. 1060805-03-9
  • Cat. No. CS-0040329
  • Purity ≥97%
  • MDL No. MFCD13185605
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FNO
  • Molecular Weight 127.12
  • Synonym(s) ABBYPHARMA AP-14-5665
  • SMILES COC1=C(F)C=NC=C1

Description

3-Fluoro-4-methoxypyridine features a fluorinated pyridine core with a methoxy group at the 4-position, delivering enhanced electron-withdrawing character and improved metabolic stability. This combination enables efficient coupling in cross-coupling reactions and facilitates incorporation into bioactive scaffolds requiring precise electronic tuning.

Application

3-Fluoro-4-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine ring via palladium-catalyzed cross-coupling reactions. Its fluorine and methoxy substituents provide orthogonal reactivity, enhancing metabolic stability and modulating electronic properties. The compound exhibits excellent bench stability, facilitates straightforward purification, and functions effectively in standard heterocyclic synthesis workflows.

Synthesis

  • Route1
    • In-stock
      4-Chloro-3-fluoropyridine|CS-W001515
      2546-56-7
    • null|null
      124-41-4
    • ~54%
    • In-stock
      3-Fluoro-4-methoxypyridine|CS-0040329
      1060805-03-9

    References

    • WO2009/103950 A1, ; Page/Page column 14 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.2293
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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