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CS-W001157 4
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Methyl 4-fluoro-2-formylbenzoate

  • CAS No. 106014-25-9

  • Cat. No. CS-0160888
  • Purity≥96%
  • MDL No.MFCD24685411
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Methyl 4-fluoro-2-formylbenzoate|CS-0160888

Structure of 106014-25-9

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Description

Methyl 4-fluoro-2-formylbenzoate features a fluorinated aromatic ring with strategically positioned formyl and ester groups, enabling direct incorporation into Suzuki-Miyaura coupling and Ullmann-type reactions. The electron-deficient benzene core enhances reactivity in cross-coupling processes, while the formyl moiety serves as a handle for subsequent functionalization via nucleophilic addition or condensation chemistry.

Application

Methyl 4-fluoro-2-formylbenzoate serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted benzimidazoles and other heterocyclic scaffolds. The ortho-formyl group facilitates electrophilic substitution and condensation reactions, while the fluorine substituent enhances metabolic stability and modulates electronic properties. Bench-stable and compatible with standard purification techniques, it functions effectively in multi-step syntheses requiring precise functional group placement.

General Information

  • CAS No. 106014-25-9
  • Cat. No. CS-0160888
  • Purity ≥96%
  • MDL No. MFCD24685411
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇FO₃
  • Molecular Weight 182.15
  • Synonym(s) 4-Fluoro-2-formyl-benzoic acid methyl ester
  • SMILES O=C(OC)C1=CC=C(F)C=C1C=O

Computational Chemistry Data

  • TPSA   43.37
  • LogP   1.4248
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group :
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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