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CS-W001157 4
Total: USD 88.00

rel-(1R,2R)-2-Fluorocyclopropanecarboxylic acid

  • CAS No. 105919-34-4

  • Cat. No. CS-0031485
  • Purity≥96%
  • MDL No.MFCD04972869

*For research and further manufacturing use only, not for direct human use.

rel-(1R,2R)-2-Fluorocyclopropanecarboxylic acid|CS-0031485

Structure of 105919-34-4

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General Information

  • CAS No. 105919-34-4
  • Cat. No. CS-0031485
  • Purity ≥96%
  • MDL No. MFCD04972869
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅FO₂
  • Molecular Weight 104.08
  • Synonym(s) (cis)-2-fluorocyclopropanecarboxylic acid
  • SMILES O=C([C@@H]1[C@H](F)C1)O

Description

rel-(1R,2R)-2-Fluorocyclopropanecarboxylic acid features a strained cyclopropane ring with stereocontrolled fluorination, delivering enhanced metabolic stability and conformational rigidity. This configuration enables precise spatial orientation in bioactive molecules, facilitating targeted interactions in medicinal chemistry applications.

Application

rel-(1R,2R)-2-Fluorocyclopropanecarboxylic acid serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of fluorinated cyclopropane-containing scaffolds. Its bench-stable nature and defined stereochemistry facilitate reliable incorporation into bioactive molecules, particularly in targeted drug discovery where cyclopropane motifs enhance metabolic stability and conformational rigidity.

Synthesis

  • Route1
    • 2-Chloro-2-fluorocyclopropanecarboxylic acid|CS-0054273
      137081-42-6
    • ~9%
    • In-stock
      rel-(1R,2R)-2-Fluorocyclopropanecarboxylic acid|CS-0031485
      105919-34-4

    References

    • Gassen, K. R.; Baasner, B. Journal of Fluorine Chemistry, 1990 , vol. 49, # 1 p. 127 - 139

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   0.429
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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