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CS-W001157 4
Total: USD 88.00

(3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine

  • CAS No. 105812-81-5

  • Cat. No. CS-W003303
  • Purity≥97%
  • MDL No.MFCD06658161

*For research and further manufacturing use only, not for direct human use.

(3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine|CS-W003303

Structure of 105812-81-5

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General Information

  • CAS No. 105812-81-5
  • Cat. No. CS-W003303
  • Purity ≥97%
  • MDL No. MFCD06658161
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₈FNO
  • Molecular Weight 223.29
  • Synonym(s) 3-Piperidinemethanol,4-(4-fluorophenyl)-1-methyl-,(3S,4R)-
  • SMILES OC[C@@H]1CN(C)CC[C@H]1C2=CC=C(F)C=C2

Application

(3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine serves as a versatile chiral building block for medicinal chemistry, enabling access to bioactive scaffolds through established functional group transformations. The hydroxymethyl group facilitates derivatization, while the 4-fluorophenyl and methylpiperidine moieties offer favorable lipophilicity and conformational control. Bench-stable and compatible with standard purification methods, it functions effectively in multistep syntheses requiring stereochemical precision.

Synthesis

  • Route1
    • null|null
      335158-58-2
    • ~77%
    • In-stock
      (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine|CS-W003303
      105812-81-5

    References

    • WO2004/5254 A1, ; Page 9 ;
  • Route2
    • null|null
      188302-25-2
    • ~81%
    • In-stock
      (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine|CS-W003303
      105812-81-5

    References

    • Tetrahedron Asymmetry, , vol. 22, # 1 p. 1 - 3
  • Route3
    • null|null
      858938-15-5
    • ~%
    • In-stock
      (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine|CS-W003303
      105812-81-5

    References

    • WO2005/63707 A1, ; Page 30 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302+H312-H315-H318-H335-H411
Precautionary Statements : P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P391-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   1.8533
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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